Ring Finger Protein 11 Inhibits Melanocortin 3 and 4 Receptor Signaling
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چکیده
منابع مشابه
Ring Finger Protein 11 Inhibits Melanocortin 3 and 4 Receptor Signaling
Intact melanocortin signaling via the G protein-coupled receptors (GPCRs), melanocortin receptor 4 (MC4R), and melanocortin receptor 3 (MC3R) is crucial for body weight maintenance. So far, no connection between melanocortin signaling and hypothalamic inflammation has been reported. Using a bimolecular fluorescence complementation library screen, we identified a new interaction partner for thes...
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Melanocortin 2 receptor (MC2R) is the only canonical ACTH receptor. Its functional expression requires the presence of an accessory protein, known as melanocortin receptor 2 accessory protein 1 (MRAP1). The vertebrate genome exhibits a paralogue gene called MRAP2, which is duplicated in zebrafish (MRAP2a and MRAP2b), although its function remains unknown. In this paper, we demonstrate that MRAP...
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ژورنال
عنوان ژورنال: Frontiers in Endocrinology
سال: 2016
ISSN: 1664-2392
DOI: 10.3389/fendo.2016.00109